Investigating a specific protein's role in blood-brain barrier dysfunction in Alzheimer's disease
A TIMEM252-dependent Microvascular Endophenotype in Alzheimer’s Disease
['FUNDING_R01'] · UNIVERSITY OF SOUTHERN CALIFORNIA · NIH-11093315
This study is looking at how a protein called TMEM252 might be causing problems with the blood-brain barrier in people with Alzheimer's and similar conditions, which could help us understand why some older adults experience memory issues, and it could lead to new treatments to protect brain health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF SOUTHERN CALIFORNIA (nih funded) |
| Locations | 1 site (Los Angeles, UNITED STATES) |
| Trial ID | NIH-11093315 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how a protein called TMEM252 contributes to blood-brain barrier (BBB) dysfunction in Alzheimer's disease and related dementias. The study aims to explore the mechanisms behind microvascular injury and how it affects cognitive decline in aging individuals. By analyzing various models of neurological disorders, the researchers will investigate whether TMEM252 is a common factor in BBB impairment and its implications for neuronal health. Patients may benefit from insights that could lead to new therapeutic strategies targeting BBB dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias, particularly those experiencing cognitive decline.
Not a fit: Patients with non-neurological conditions or those not diagnosed with Alzheimer's disease or related dementias may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect the brain's blood supply and improve cognitive function in Alzheimer's patients.
How similar studies have performed: Previous research has shown promising results in understanding BBB dysfunction in neurological disorders, suggesting that this approach may yield valuable insights.
Where this research is happening
Los Angeles, UNITED STATES
- UNIVERSITY OF SOUTHERN CALIFORNIA — Los Angeles, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHAO, ZHEN — UNIVERSITY OF SOUTHERN CALIFORNIA
- Study coordinator: ZHAO, ZHEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.