Investigating a specific enzyme for creating drug metabolites
Characterizing and engineering toluene o-xylene monooxygenase for the synthesis of common drug metabolites
['FUNDING_OTHER'] · CALIFORNIA STATE UNIVERSITY-STANISLAUS · NIH-10674949
This study is working on making a special enzyme better so that it can help create important parts of medicines more efficiently, which could lead to safer and more effective treatments for patients like you.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CALIFORNIA STATE UNIVERSITY-STANISLAUS (nih funded) |
| Locations | 1 site (TURLOCK, UNITED STATES) |
| Trial ID | NIH-10674949 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding and improving the enzyme toluene o-xylene monooxygenase (ToMO) to enhance the production of drug metabolites. By engineering this enzyme, the project aims to create more efficient methods for synthesizing these metabolites, which are crucial for evaluating drug safety and effectiveness. The approach involves using advanced protein engineering techniques to modify the enzyme's activity and substrate range, potentially leading to better outcomes in drug development. Patients may benefit indirectly as this research could lead to safer and more effective medications.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals involved in clinical trials for new medications or those affected by conditions requiring novel drug therapies.
Not a fit: Patients who are not involved in drug development or who do not require new medications may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of safer and more effective drugs by improving the understanding of drug metabolites.
How similar studies have performed: Other research has shown promise in using engineered enzymes for drug metabolism, indicating that this approach could be successful.
Where this research is happening
TURLOCK, UNITED STATES
- CALIFORNIA STATE UNIVERSITY-STANISLAUS — TURLOCK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHARA, GONUL — CALIFORNIA STATE UNIVERSITY-STANISLAUS
- Study coordinator: SCHARA, GONUL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.