Investigating a small molecule that activates autophagy to improve insulin signaling and reduce Alzheimer's disease symptoms in mice.
Official title: Effect of small molecule activator of autophagy on insulin signaling, senescence, and neuropathology in mouse models of Alzheimer's disease
Funded at Florida International University · NIH-11057961 · Data updated 2026-11-12
This study is looking at how a special compound called TPI-132 might help improve insulin signaling and brain health in mice with Alzheimer's disease, with the hope that it could lead to new treatments for people living with this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida International University NIH-funded |
| Lab location | 1 site (Miami, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $479,375 |
| NIH project number | 1R61AG086971-01A1 |
| Project ID | NIH-11057961 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with Alzheimer's disease or those at risk of developing it, particularly older adults.
✕Less likely to help
Patients with early-stage Alzheimer's disease or those without significant cognitive impairment may not benefit from this research.
What this research studies
This research explores the effects of a small molecule activator of autophagy, TPI-132, on insulin signaling and neurodegeneration in mouse models of Alzheimer's disease. The study aims to understand how enhancing autophagy can potentially reverse age-related cellular changes and improve cognitive function. By using advanced screening techniques, researchers will assess the impact of TPI-132 on various biological markers associated with Alzheimer's pathology. The findings could provide insights into new therapeutic strategies for Alzheimer's patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function and slow the progression of Alzheimer's disease.
How similar studies have gone: Previous research has shown promise in using autophagy activators to improve neurodegenerative conditions, suggesting a potential for success in this approach.
Where this research is happening
-
Florida International University
Miami, United States Active
Researchers
- Principal investigator: Lakshmana, Madepalli Krishnappa — Florida International University
- Study coordinator: Lakshmana, Madepalli Krishnappa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.