Investigating a receptor's role in pain processing
Official title: Validation of Neuropilin-1 Receptor Signaling in Nociceptive Processing
Funded at University of Florida · NIH-11138856 · Data updated 2026-11-12
This study is looking at how a specific receptor in the body affects pain, especially when it becomes long-lasting, and it aims to find out if blocking this receptor can help reduce that pain, which could lead to new ways to treat chronic pain.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | January 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $1,926,350 |
| NIH project number | 7RF1NS131165-02 |
| Project ID | NIH-11138856 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing chronic pain, particularly those with neuropathic pain conditions.
✕Less likely to help
Patients with acute pain or those not experiencing chronic pain may not benefit from this research.
What this research studies
This research focuses on understanding how the Neuropilin-1 receptor influences pain responses in the body, particularly in conditions where pain becomes chronic. By examining the interaction between this receptor and a signaling molecule called vascular endothelial growth factor-A (VEGFA), the study aims to uncover mechanisms that lead to heightened pain sensitivity. The researchers will use various models to test how blocking this receptor can potentially alleviate pain, offering insights into new treatment strategies for chronic pain conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively reduce chronic pain for patients.
How similar studies have gone: Previous research has shown promise in targeting similar pathways for pain management, suggesting potential for success in this approach.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Khanna, Rajesh — University of Florida
- Study coordinator: Khanna, Rajesh
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.