Investigating a receptor's role in maintaining joint cartilage health
Official title: Molecular Regulatory Mechanism of a Cartilage-Enriched GPCR in Joint Maintenance
Funded at University of Southern California · NIH-11048992 · Data updated 2026-11-12
This study is looking at how a special receptor called ADGRG6 helps keep cartilage healthy in our joints, especially for people with osteoarthritis, to find new ways to improve joint health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | April 10, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $426,889 |
| NIH project number | 1R01AR083966-01A1 |
| Project ID | NIH-11048992 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are experiencing symptoms of osteoarthritis.
✕Less likely to help
Patients with joint issues unrelated to osteoarthritis may not benefit from this research.
What this research studies
This research focuses on understanding how a specific receptor, known as ADGRG6, contributes to the maintenance of cartilage in joints, particularly in the context of osteoarthritis (OA). The study will utilize advanced animal models to explore the signaling pathways involved in cartilage health and how their disruption leads to OA. By examining the effects of genetic modifications on chondrocytes, the research aims to uncover potential therapeutic targets for improving joint health in patients suffering from OA.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent cartilage degeneration in osteoarthritis patients.
How similar studies have gone: Previous research has shown promising results in targeting GPCRs for joint health, indicating that this approach may lead to significant advancements in osteoarthritis treatment.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Liu, Zhaoyang — University of Southern California
- Study coordinator: Liu, Zhaoyang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.