Investigating a receptor's role in lung damage from radiation therapy
The Thromboxane-Prostanoid Receptor in Radiation-Induced Pulmonary Fibrosis
['FUNDING_R01'] · VANDERBILT UNIVERSITY MEDICAL CENTER · NIH-10912036
This study is exploring how radiation therapy can harm the lungs and is looking at a specific receptor that might be involved, with the hope of finding new ways to protect patients from lung damage during cancer treatment.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (NASHVILLE, UNITED STATES) |
| Trial ID | NIH-10912036 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how radiation therapy can lead to lung injury, specifically looking at a receptor called the thromboxane-prostanoid receptor (TPr) that may play a key role in this process. By studying how this receptor activates fibroblasts, the research aims to find ways to limit the development of radiation-induced pulmonary fibrosis. The approach includes both pharmacological methods to inhibit the receptor and genetic techniques to explore its function in animal models. The ultimate goal is to identify new treatment strategies that could protect patients from lung damage during cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients receiving thoracic radiotherapy who are at risk of developing radiation-induced lung fibrosis.
Not a fit: Patients who have not undergone radiation therapy or those with pre-existing lung conditions unrelated to radiation exposure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent or reduce lung damage in patients undergoing radiation therapy for cancer.
How similar studies have performed: Previous studies have shown promising results in targeting similar pathways to mitigate lung injury, suggesting that this approach may be effective.
Where this research is happening
NASHVILLE, UNITED STATES
- VANDERBILT UNIVERSITY MEDICAL CENTER — NASHVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WEST, JAMES D — VANDERBILT UNIVERSITY MEDICAL CENTER
- Study coordinator: WEST, JAMES D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.