Investigating a receptor's role in eye scarring related to vision loss
Adenosine receptor 2A in subretinal fibrosis
This study is looking at how a specific receptor in the eye might play a role in a serious condition that can cause vision loss for people with age-related macular degeneration, and it's using mice to find out how different cells contribute to this problem, which could help develop new treatments to protect your eyesight.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11234994 on NIH RePORTER |
What this research studies
This research focuses on subretinal fibrosis, a severe condition that leads to vision impairment in patients with neovascular age-related macular degeneration. The study aims to understand the role of adenosine receptor 2A in the development of this fibrosis by examining how various cell types contribute to the condition. By using mouse models, researchers will explore the cellular and molecular mechanisms involved, which could lead to new therapeutic strategies for preventing or treating this debilitating eye condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with neovascular age-related macular degeneration who are at risk of developing subretinal fibrosis.
Not a fit: Patients with other forms of macular degeneration or those without any retinal conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent vision loss in patients suffering from subretinal fibrosis.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in other vascular diseases, suggesting potential for success in this area as well.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Huo, Yuqing — Baylor College of Medicine
- Study coordinator: Huo, Yuqing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.