Investigating a protein's role in retinal diseases and vision.
Official title: IRBP in the visual cycles and retinal diseases
Funded at Lsu Health Sciences Center · NIH-11080868 · Data updated 2026-11-12
This study is looking at a protein important for vision to see how changes in it can cause eye diseases like retinitis pigmentosa and childhood-onset retinal dystrophy, using a special mouse model to find out how these changes affect sight and explore ways to help improve vision for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lsu Health Sciences Center NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $375,000 |
| NIH project number | 5R01EY036015-02 |
| Project ID | NIH-11080868 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children and adults with genetic mutations linked to retinal diseases like retinitis pigmentosa or childhood-onset retinal dystrophy.
✕Less likely to help
Patients with retinal diseases not associated with IRBP mutations may not benefit from this research.
What this research studies
This research focuses on the interphotoreceptor retinoid-binding protein (IRBP), which is crucial for visual function. It aims to understand how mutations in this protein lead to retinal diseases such as retinitis pigmentosa and childhood-onset retinal dystrophy. Using a specially developed mouse model, the researchers will explore the mechanisms behind these mutations and their effects on vision. The study will also investigate potential ways to rescue visual function in affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for retinal diseases, potentially improving vision for affected patients.
How similar studies have gone: Previous research has shown promise in understanding the role of IRBP in retinal diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Lsu Health Sciences Center
New Orleans, United States Active
Researchers
- Principal investigator: Jin, Minghao — Lsu Health Sciences Center
- Study coordinator: Jin, Minghao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.