Investigating a protein's role in reducing lung inflammation in asthma
Transmembrane Protein 178 as a Novel Endogenous Inhibitory Mechanism in Asthma
This study is looking at a protein called Tmem178 to see how it helps reduce lung inflammation in people with asthma, and it aims to find new ways to treat asthma by understanding how this protein works in the lungs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11164839 on NIH RePORTER |
What this research studies
This research focuses on understanding how a specific protein, Transmembrane Protein 178 (Tmem178), helps to inhibit lung inflammation associated with asthma. The study will explore how Tmem178 functions in bronchial epithelial cells and how its expression changes with asthma severity. Researchers will use a combination of cell cultures, mouse models, and genetic analysis to investigate the mechanisms by which Tmem178 regulates inflammation and airway responsiveness. By identifying the role of this protein, the research aims to uncover new therapeutic targets for asthma management.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with asthma, particularly those experiencing severe symptoms.
Not a fit: Patients with mild asthma or those who do not have asthma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better control asthma symptoms and reduce inflammation in patients.
How similar studies have performed: Previous research has shown promising results in targeting similar mechanisms for asthma treatment, indicating potential for success in this approach.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Chiarella, Sergio E — Mayo Clinic Rochester
- Study coordinator: Chiarella, Sergio E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.