Investigating a protein's role in pulmonary hypertension
Official title: Targeting mitoNEET in pulmonary hypertension
Funded at Emory University · NIH-11131838 · Data updated 2026-11-12
This study is looking at how changes in tiny parts of your cells, called mitochondria, might affect pulmonary hypertension, especially in people with lung disease, and it hopes to find new ways to help those who don’t have many treatment options right now.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | June 1, 2025 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $596,809 |
| NIH project number | 1R01HL175515-01A1 |
| Project ID | NIH-11131838 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with pulmonary hypertension secondary to lung disease.
✕Less likely to help
Patients with pulmonary hypertension not related to lung disease or those with other unrelated conditions may not benefit from this research.
What this research studies
This research focuses on pulmonary hypertension (PH), a serious condition characterized by increased pressure in the pulmonary arteries, which can lead to significant health issues. The study aims to understand how altered mitochondrial function contributes to PH, particularly in patients with lung disease. Researchers will explore a specific protein called mitoNEET, which is involved in mitochondrial metabolism and may play a role in the disease's progression. By identifying new therapeutic targets related to mitoNEET, the research seeks to develop effective treatments for patients who currently have limited options.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve the management and outcomes of patients with pulmonary hypertension.
How similar studies have gone: Preliminary data from similar studies have shown promising results in targeting mitoNEET, indicating potential for success in this approach.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Hart, C Michael — Emory University
- Study coordinator: Hart, C Michael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.