Investigating a protein's role in protecting dopamine neurons
Official title: Functional analysis of KCNK12 in dopaminergic neuroprotection
Funded at University of Alabama in Tuscaloosa · NIH-10665836 · Data updated 2026-11-12
This study is looking at a protein called KCNK12 to see how it helps protect brain cells that produce dopamine, which are important for conditions like Parkinson's disease, using tiny roundworms to learn more about how it works and how we might help keep those cells healthy.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama in Tuscaloosa NIH-funded |
| Lab location | 1 site (Tuscaloosa, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $143,561 |
| NIH project number | 1R03TR004460-01 |
| Project ID | NIH-10665836 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for or diagnosed with neurodegenerative diseases affecting dopamine neurons.
✕Less likely to help
Patients with neurodegenerative conditions unrelated to dopamine neuron degeneration may not receive benefit from this research.
What this research studies
This research focuses on understanding the function of the KCNK12 protein, which is believed to play a crucial role in protecting dopamine neurons from degeneration. Using the roundworm C. elegans as a model, the study examines how this protein interacts with cellular stress responses, particularly in the context of neurodegenerative diseases like Parkinson's. By exploring the genetic and molecular mechanisms involved, the research aims to uncover potential therapeutic targets for neuroprotection.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for protecting dopamine neurons, potentially benefiting patients with neurodegenerative diseases such as Parkinson's.
How similar studies have gone: Previous research has shown promise in targeting similar proteins for neuroprotection, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Alabama in Tuscaloosa
Tuscaloosa, United States Active
Researchers
- Principal investigator: Caldwell, Kim a — University of Alabama in Tuscaloosa
- Study coordinator: Caldwell, Kim a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.