Investigating a protein's role in obsessive-compulsive disorder
Functional study of the role of SAPAP3 postsynaptic density protein on dorsolateral striatal cholinergic interneurons
This study is looking at how a protein called SAPAP3 affects certain brain cells related to obsessive-compulsive disorder (OCD), with the hope of finding new ways to better understand and treat OCD symptoms.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-10907676 on NIH RePORTER |
What this research studies
This research focuses on understanding how the SAPAP3 protein affects cholinergic interneurons in the brain, particularly in relation to obsessive-compulsive disorder (OCD). By using advanced imaging techniques, the study aims to explore the cellular and circuit-level dysfunctions associated with OCD. The research will involve examining how changes in this protein influence behavior and brain function, potentially leading to new insights into OCD treatment. Patients may benefit from findings that could improve understanding and management of OCD symptoms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with obsessive-compulsive disorder.
Not a fit: Patients without a diagnosis of obsessive-compulsive disorder or those with other unrelated psychiatric conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better-targeted treatments for obsessive-compulsive disorder.
How similar studies have performed: Previous research has shown promising results in understanding the role of synaptic proteins in psychiatric disorders, suggesting that this approach may yield valuable insights.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Baez, Alexander Theodor — State University New York Stony Brook
- Study coordinator: Baez, Alexander Theodor
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.