Investigating a protein's role in mast cell growth related to asthma
MCEMP1 is an adaptor for KIT receptor for mast cell proliferation
This study is looking at a protein called MCEMP1 in mast cells, which are important for allergies and asthma, to see how it affects asthma symptoms and lung inflammation, and it could help find better ways to manage asthma in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11015871 on NIH RePORTER |
What this research studies
This research focuses on understanding the function of Mast Cell Expressed Membrane Protein 1 (MCEMP1) in mast cells, which are crucial for allergic responses and asthma exacerbations. The study will explore how MCEMP1 interacts with the KIT receptor to influence mast cell proliferation and its potential role in worsening asthma symptoms. By using mouse models, researchers will assess how the absence of MCEMP1 affects mast cell behavior and lung inflammation during asthma attacks. This could lead to new insights into asthma management and treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with asthma, particularly those experiencing frequent exacerbations.
Not a fit: Patients with non-allergic asthma or those without significant mast cell involvement may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for asthma, potentially improving treatment options for patients.
How similar studies have performed: Previous research has shown that targeting mast cell signaling pathways can lead to significant improvements in asthma management, suggesting a promising avenue for this investigation.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Choi, Youn Jung — Cedars-Sinai Medical Center
- Study coordinator: Choi, Youn Jung
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.