Investigating a protein's role in lung scarring
Official title: A Novel PAI-1 Function Drives Lung Fibrosis
Funded at University of Michigan at Ann Arbor · NIH-10984974 · Data updated 2026-11-12
This study is looking at how a protein called PAI-1 affects lung scarring, with the hope of finding new ways to help people with lung conditions like Idiopathic Pulmonary Fibrosis (IPF).
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | December 15, 2022 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $635,881 |
| NIH project number | 5R01HL163870-03 |
| Project ID | NIH-10984974 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Idiopathic Pulmonary Fibrosis or other related lung diseases characterized by fibrosis.
✕Less likely to help
Patients with lung conditions not related to fibrosis or those with advanced stages of lung disease may not benefit from this research.
What this research studies
This research focuses on understanding how a protein called plasminogen activator inhibitor-1 (PAI-1) contributes to lung fibrosis, a condition characterized by progressive scarring of lung tissue. By studying animal models, researchers aim to uncover the mechanisms by which PAI-1 promotes fibrosis and how it interacts with other proteins involved in the disease process. The goal is to identify new therapeutic targets that could lead to more effective treatments for patients suffering from conditions like Idiopathic Pulmonary Fibrosis (IPF).
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve the quality of life and survival rates for patients with lung fibrosis.
How similar studies have gone: Previous research has shown promising results in targeting PAI-1 for treating lung fibrosis, indicating a potential for success in this novel approach.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Sisson, Thomas H — University of Michigan at Ann Arbor
- Study coordinator: Sisson, Thomas H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.