Investigating a protein's role in lung fibrosis
Bromodomain-containing Protein 4 in Profibrotic Gene Expression and Lung Fibrosis
This study is looking at how a protein called Brd4 affects the genes that make lung scarring worse in people with idiopathic pulmonary fibrosis (IPF), and by blocking Brd4, researchers hope to find a new way to help improve lung health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Old Dominion University NIH-funded |
| Lab location | 1 site (Norfolk, United States) |
| Project ID | NIH-11017828 on NIH RePORTER |
What this research studies
This research focuses on idiopathic pulmonary fibrosis (IPF), a serious lung disease characterized by changes in gene expression due to epigenetic alterations. The study aims to understand how bromodomain-containing protein 4 (Brd4) influences the expression of genes that contribute to fibrosis in the lungs. By inhibiting Brd4, researchers hope to reduce the activity of these profibrotic genes, potentially offering a new therapeutic approach. The methodology involves examining chromatin accessibility and gene expression changes in response to Brd4 inhibition.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with idiopathic pulmonary fibrosis.
Not a fit: Patients with other forms of lung disease or those without a diagnosis of pulmonary fibrosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively reduce lung fibrosis and improve patient outcomes.
How similar studies have performed: Previous research has shown promise in targeting epigenetic mechanisms for treating fibrosis, suggesting that this approach may yield beneficial results.
Where this research is happening
Norfolk, United States
- Old Dominion University — Norfolk, United States (Active)
Researchers
- Principal investigator: Sanders, Yan — Old Dominion University
- Study coordinator: Sanders, Yan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.