Investigating a protein's role in lung blood vessel disease
Role of Endothelial Anoctamin-1 in Pulmonary Arterial Hypertension
['FUNDING_R01'] · OCEAN STATE RESEARCH INSTITUTE, INC. · NIH-10449284
This study is looking at how a protein called Anoctamin-1 affects the growth of certain cells in the lungs of people with pulmonary arterial hypertension (PAH), with the hope of finding new treatments that could help improve their health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OCEAN STATE RESEARCH INSTITUTE, INC. (nih funded) |
| Locations | 1 site (PROVIDENCE, UNITED STATES) |
| Trial ID | NIH-10449284 on ClinicalTrials.gov |
What this research studies
This research focuses on pulmonary arterial hypertension (PAH), a serious condition that affects blood vessels in the lungs. It aims to understand how a specific protein, Anoctamin-1, contributes to the abnormal growth and survival of endothelial cells in PAH. By exploring the mechanisms behind this protein's activity, the research seeks to identify new treatment strategies that could reduce harmful cell proliferation and promote cell death in these dysfunctional cells. Patients may benefit from potential therapies that target these processes to improve their condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary arterial hypertension who are experiencing significant symptoms and have limited treatment options.
Not a fit: Patients with other forms of pulmonary hypertension or those without significant endothelial dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively reduce the severe vascular remodeling associated with pulmonary arterial hypertension.
How similar studies have performed: While the specific approach of targeting Anoctamin-1 in PAH is novel, similar strategies targeting dysfunctional endothelial cells have shown promise in other vascular diseases.
Where this research is happening
PROVIDENCE, UNITED STATES
- OCEAN STATE RESEARCH INSTITUTE, INC. — PROVIDENCE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHOUDHARY, GAURAV — OCEAN STATE RESEARCH INSTITUTE, INC.
- Study coordinator: CHOUDHARY, GAURAV
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer