Investigating a protein's role in liver disease progression
Official title: Hepatic SLC25a25 in Steatotic Liver Disease Progression
Funded at Lsu Pennington Biomedical Research Ctr · NIH-10903426 · Data updated 2026-11-12
This study is looking at how a protein called SLC25a25 influences liver health in people with obesity who have a serious liver condition called MASH, to find new ways to help treat it.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lsu Pennington Biomedical Research Ctr NIH-funded |
| Lab location | 1 site (Baton Rouge, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $42,467 |
| NIH project number | 1F31DK139728-01 |
| Project ID | NIH-10903426 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with obesity who are at risk for or diagnosed with metabolic dysfunction-associated steatohepatitis.
✕Less likely to help
Patients without obesity or those who do not have metabolic liver disease may not benefit from this research.
What this research studies
This research focuses on understanding how the protein SLC25a25 affects the progression of metabolic dysfunction-associated steatohepatitis (MASH), a serious liver condition. By examining human samples from patients with obesity, the study aims to uncover the mechanisms by which SLC25a25 regulates energy production in liver cells and its impact on fat accumulation. The research will involve both cross-sectional analyses of patient samples and experimental models to assess the protein's function in liver health. Ultimately, the goal is to identify potential therapeutic targets for treating MASH.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies for patients suffering from metabolic liver diseases.
How similar studies have gone: Previous research has shown promising results in targeting mitochondrial functions for liver disease treatment, suggesting potential for success in this approach.
Where this research is happening
-
Lsu Pennington Biomedical Research Ctr
Baton Rouge, United States Active
Researchers
- Principal investigator: Heintz, Elizabeth C — Lsu Pennington Biomedical Research Ctr
- Study coordinator: Heintz, Elizabeth C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.