Investigating a protein's role in liver disease and fibrosis
RECK regulation of NASH and fibrosis
This study is looking at how a protein called RECK affects liver health in people with nonalcoholic fatty liver disease (NAFLD) and aims to find new ways to help treat this condition as it can lead to more serious issues like NASH and fibrosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-11085067 on NIH RePORTER |
What this research studies
This research focuses on nonalcoholic fatty liver disease (NAFLD), which can progress to more severe conditions like nonalcoholic steatohepatitis (NASH) and fibrosis. The study aims to explore the role of a specific protein called RECK, which is involved in regulating inflammation and fibrosis in the liver. By using advanced mouse models and cellular studies, researchers will assess how changes in RECK levels affect liver health and disease progression. The ultimate goal is to identify new therapeutic targets for treating these liver conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with nonalcoholic fatty liver disease or its more severe forms.
Not a fit: Patients with liver diseases caused by alcohol consumption or other non-metabolic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients suffering from NASH and liver fibrosis.
How similar studies have performed: While the approach of targeting RECK in liver disease is innovative, similar studies have shown promise in understanding the mechanisms of liver inflammation and fibrosis.
Where this research is happening
Columbia, United States
- University of Missouri-Columbia — Columbia, United States (Active)
Researchers
- Principal investigator: Rector, Randy Scott — University of Missouri-Columbia
- Study coordinator: Rector, Randy Scott
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.