Investigating a protein's role in inherited heart rhythm disorders
Official title: The Role of End-Binding Protein 2 and Microtubule Network in Inherited Cardiac Arrhythmias
Funded at Brigham and Women's Hospital · NIH-11268004 · Data updated 2026-11-12
This study is looking into the genetic causes of Brugada syndrome, a heart condition that can be dangerous for young people, to help find better ways to diagnose and understand it, especially by exploring how a specific protein interacts with other genes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 18, 2025 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $248,363 |
| NIH project number | 4R00HL161472-03 |
| Project ID | NIH-11268004 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include young individuals with a family history of cardiac arrhythmias or those diagnosed with Brugada syndrome.
✕Less likely to help
Patients with acquired arrhythmias not linked to genetic factors may not benefit from this research.
What this research studies
This research focuses on inherited cardiac arrhythmias, particularly Brugada syndrome, which can lead to sudden cardiac death in young individuals. The study aims to identify genetic factors associated with these conditions, specifically examining the role of the microtubule plus end-binding protein 2 (EB2) and its interactions with other genes. By analyzing genetic data and conducting experiments on heart cells, the research seeks to uncover mechanisms that contribute to arrhythmias and improve genetic diagnosis for affected patients.
Why it matters
Potential benefit: If successful, this research could lead to better genetic understanding and diagnostic tools for inherited cardiac arrhythmias, potentially saving lives.
How similar studies have gone: Previous research has successfully identified genetic factors in cardiac arrhythmias, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Chiang, David Yi-Eng — Brigham and Women's Hospital
- Study coordinator: Chiang, David Yi-Eng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.