Investigating a protein's role in heart failure among veterans
Official title: A Stress Inducible Protein Sestrin2 in Heart Failure
Funded at G V Sonny Montgomery VA Medcial Center · NIH-11109624 · Data updated 2026-11-12
This study is looking at how a protein called Sestrin2 affects heart health, especially in older veterans who may have other health problems like obesity and diabetes, to help find new ways to treat heart failure.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | G V Sonny Montgomery VA Medcial Center NIH-funded |
| Lab location | 1 site (Jackson, United States) |
| Project start | April 1, 2022 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| NIH project number | 5I01BX005625-05 |
| Project ID | NIH-11109624 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are veterans experiencing heart failure, particularly those with comorbid conditions like obesity and diabetes.
✕Less likely to help
Patients without heart failure or those who are not veterans may not benefit from this research.
What this research studies
This research focuses on understanding how a protein called Sestrin2 contributes to heart failure, particularly in aging veterans who often have multiple health issues like obesity and diabetes. By studying both basic biology and practical applications, the research aims to uncover the mechanisms by which Sestrin2 affects heart function and the progression of heart disease. The team will use animal models to explore how the absence of this protein influences heart health under stress conditions, which could lead to new treatments for heart failure.
Why it matters
Potential benefit: If successful, this research could lead to novel therapies that improve heart function and quality of life for patients with heart failure.
How similar studies have gone: Other research has shown promising results in understanding the role of stress-inducible proteins in heart disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
G V Sonny Montgomery VA Medcial Center
Jackson, United States Active
Researchers
- Principal investigator: Li, Ji — G V Sonny Montgomery VA Medcial Center
- Study coordinator: Li, Ji
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.