Investigating a protein's role in healing jawbone fractures
Official title: NG2/CSPG4 in Mandibular Endochondral Fracture Healing
Funded at University of Illinois at Chicago · NIH-10926829 · Data updated 2026-11-12
This study is looking at how a protein called NG2/CSPG4 influences the healing of jawbone fractures, especially when healing takes longer than usual, to help find better treatments for people with these types of injuries.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project start | September 1, 2023 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $54,774 |
| NIH project number | 5F30DE033287-02 |
| Project ID | NIH-10926829 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced mandibular fractures, particularly those with delayed healing.
✕Less likely to help
Patients with stable mandibular fractures that heal normally may not benefit from this research.
What this research studies
This research focuses on understanding how a specific protein, NG2/CSPG4, affects the healing process of fractures in the jawbone, particularly in cases where healing is delayed. Using a mouse model, the study aims to explore the molecular pathways involved in the transition from cartilage to bone during the healing process. By identifying these pathways, the research seeks to improve treatment strategies for patients with mandibular fractures, which are common but can lead to complications if not healed properly.
Why it matters
Potential benefit: If successful, this research could lead to improved healing methods for jawbone fractures, enhancing recovery and reducing complications for patients.
How similar studies have gone: While the specific focus on NG2/CSPG4 in mandibular fracture healing is novel, similar studies have shown promise in understanding fracture healing mechanisms.
Where this research is happening
-
University of Illinois at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Banks, Jonathan Matthew — University of Illinois at Chicago
- Study coordinator: Banks, Jonathan Matthew
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.