Investigating a protein's role in dementia after brain bleeding.
Official title: Targeting receptor interacting protein kinase-1 in the chronic period of intracerebral hemorrhage
Funded at Massachusetts General Hospital · NIH-11000856 · Data updated 2026-11-12
This study is looking at how a protein called RIPK-1 might play a role in memory problems for younger people who have had a brain bleed, with the goal of finding ways to help prevent dementia in these patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $439,701 |
| NIH project number | 5R01NS131281-02 |
| Project ID | NIH-11000856 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have experienced an intracerebral hemorrhage and are at risk of developing vascular cognitive impairment or dementia.
✕Less likely to help
Patients who have not experienced an intracerebral hemorrhage or those with other forms of dementia unrelated to vascular issues may not benefit from this research.
What this research studies
This research focuses on understanding how a specific protein, receptor interacting protein kinase-1 (RIPK-1), contributes to cognitive decline in patients who have experienced intracerebral hemorrhage (ICH). The study aims to uncover the mechanisms behind the rapid progression to dementia observed in ICH survivors, particularly in younger individuals. By examining the effects of RIPK-1 on the blood-brain barrier and cognitive function, the research seeks to identify potential therapeutic targets for preventing dementia in these patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or slow down dementia in patients who have suffered from intracerebral hemorrhage.
How similar studies have gone: Other research has shown promising results in targeting similar pathways in dementia, suggesting that this approach could be effective.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Whalen, Michael J — Massachusetts General Hospital
- Study coordinator: Whalen, Michael J
Related research
Other NIH-funded projects on the same topics.
-
Anticoagulation in ICH Survivors with Atrial Fibrillation and Small Vessel Disease
This project looks at how to safely use blood-thinning medicines in people who survived a brain bleed and also have atrial fibrillation and small vessel disease.
-
Statin use after lobar intracerebral hemorrhage
This trial compares continuing versus stopping statins in people who had a lobar intracerebral hemorrhage to see how that affects repeat brain bleeds, strokes, heart attacks, and recovery over two years.
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Statin use after lobar brain hemorrhage
This trial compares stopping versus continuing statin medicine in people who had a lobar brain bleed to learn effects on repeat bleeding and future heart or stroke events.
-
Blocking red blood cell death after brain hemorrhage
A study at Yale is exploring whether stopping a specific kind of red blood cell death after a brain hemorrhage could improve recovery.
-
Targeting HDAC3 to reduce brain damage after a brain bleed
This project will test whether blocking a protein called HDAC3 can reduce inflammation and improve recovery after an intracerebral hemorrhage (brain bleed).
-
Silent brain injuries after brain bleed may predict dementia risk
A study using MRI and cognitive tests to see if hidden brain injuries after spontaneous intracerebral hemorrhage help forecast later cognitive decline.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.