Investigating a protein's role in chronic pain sensitivity
Official title: Role of Scn1b in Susceptibility to Neuropathic Pain
Funded at University of California Berkeley · NIH-10846155 · Data updated 2026-11-12
This study is looking at how a specific protein might affect why some people experience more neuropathic pain than others, with the goal of finding new ways to help manage this tough condition better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project start | June 19, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $415,519 |
| NIH project number | 1R21NS136075-01 |
| Project ID | NIH-10846155 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from neuropathic pain or those who have experienced nerve injuries.
✕Less likely to help
Patients with acute pain conditions unrelated to neuropathic pain may not benefit from this research.
What this research studies
This research focuses on understanding how the SCN1B protein influences susceptibility to neuropathic pain, a chronic condition that significantly impacts many individuals. By studying genetic variations in mouse models, the researchers aim to uncover the mechanisms that contribute to different pain experiences among individuals. The project seeks to identify potential therapeutic targets and biomarkers that could lead to better treatments for neuropathic pain. This work is crucial as current pain management strategies are often ineffective.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that more effectively manage or prevent neuropathic pain.
How similar studies have gone: Previous research has shown promise in exploring genetic factors related to pain sensitivity, making this approach both relevant and potentially impactful.
Where this research is happening
-
University of California Berkeley
Berkeley, United States Active
Researchers
- Principal investigator: Lumpkin, Ellen a — University of California Berkeley
- Study coordinator: Lumpkin, Ellen a
Related research
Other NIH-funded projects on the same topics.
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-
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Parmodulins with Low Abuse Potential for Neuropathic Pain
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.