Investigating a protein's role in childhood cancer treatment
CAMKV Kinase Signaling in Neuroblastoma
This study is looking at a protein called CAMKV to see how it helps neuroblastoma, a tough cancer that affects kids, and is testing new treatments that could block this protein to help shrink tumors and improve care for children with high-risk neuroblastoma.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Research Institute NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-10843767 on NIH RePORTER |
What this research studies
This research focuses on neuroblastoma, a common and aggressive cancer in children. It aims to understand how a specific protein, CAMKV, contributes to the development of this cancer and explores the potential of inhibiting this protein as a treatment. The researchers will use mouse models to test the effectiveness of CAMKV inhibitors, which have shown promise in preliminary studies by reducing tumor growth. By identifying CAMKV as both a biomarker and a therapeutic target, the research seeks to pave the way for new treatments for high-risk neuroblastoma patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with high-risk neuroblastoma.
Not a fit: Patients with low-risk neuroblastoma or other types of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies that improve outcomes for children with high-risk neuroblastoma.
How similar studies have performed: Other research has shown success in targeting similar pathways in cancer treatment, indicating potential for this approach.
Where this research is happening
Washington, United States
- Children's Research Institute — Washington, United States (Active)
Researchers
- Principal investigator: Yang, Jianhua — Children's Research Institute
- Study coordinator: Yang, Jianhua
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.