Investigating a protein's role in blood vessel stability and repair
Official title: Protein tyrosine phosphatase non-receptor 14 in vascular stability and remodeling
Funded at University of California, San Francisco · NIH-11052530 · Data updated 2026-11-12
This study is looking at a protein called PTPN14 to see how it helps keep blood vessels healthy, which is important for good circulation and preventing problems like lung injuries, and it aims to find new ways to help people with genetic disorders that affect their blood vessels.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | March 15, 2023 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $642,659 |
| NIH project number | 5R01HL164891-03 |
| Project ID | NIH-11052530 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults with genetic disorders affecting blood vessel function or those at risk for acute lung injury.
✕Less likely to help
Patients without vascular-related conditions or those under 21 years old may not benefit from this research.
What this research studies
This research focuses on understanding how a specific protein, PTPN14, contributes to the stability and remodeling of blood vessels, which is crucial for maintaining healthy circulation and preventing conditions like acute lung injury. The study will explore the molecular mechanisms involved in vascular homeostasis, particularly in the context of genetic disorders that affect blood vessel function. By examining how PTPN14 interacts with other molecular players, the research aims to uncover potential therapeutic targets for improving vascular health in patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for conditions related to vascular instability, such as acute lung injury and hereditary hemorrhagic telangiectasia.
How similar studies have gone: Previous research has shown promising results in understanding the role of similar molecular mechanisms in vascular health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Akhurst, Rosemary J — University of California, San Francisco
- Study coordinator: Akhurst, Rosemary J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.