Investigating a protein's role in abdominal aortic aneurysm development
Official title: Dedicator of cytokinesis 2 in abdominal aortic aneurysm
Funded at University of Missouri-Columbia · NIH-10417112 · Data updated 2026-11-12
This study is looking at how a protein called DOCK2 affects inflammation and the weakening of blood vessels that can lead to abdominal aortic aneurysms (AAA), with the hope of finding new treatments for this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project start | July 1, 2019 |
| Project end | June 30, 2025 |
| Funding year | 2022 |
| Award (this year) | $523,201 |
| NIH project number | 5R01HL147313-05 |
| Project ID | NIH-10417112 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for abdominal aortic aneurysms, particularly those with a family history or other risk factors.
✕Less likely to help
Patients who do not have abdominal aortic aneurysms or related vascular conditions may not benefit from this research.
What this research studies
This research focuses on understanding how a specific protein, dedicator of cytokinesis 2 (DOCK2), contributes to the inflammation and weakening of blood vessels that lead to abdominal aortic aneurysms (AAA). By studying the mechanisms behind vascular inflammation and extracellular matrix degradation, the research aims to identify potential therapeutic targets. The approach involves using mouse models to observe the effects of DOCK2 deficiency on aneurysm formation and related inflammatory processes. If successful, this research could pave the way for new treatments for AAA, which currently lacks effective pharmacological options.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating abdominal aortic aneurysms.
How similar studies have gone: Other research has shown promising results in understanding the role of inflammatory processes in aneurysm formation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Missouri-Columbia
Columbia, United States Active
Researchers
- Principal investigator: Chen, Shiyou — University of Missouri-Columbia
- Study coordinator: Chen, Shiyou
Related research
Other NIH-funded projects on the same topics.
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How the small regulator miR-146a affects abdominal aortic aneurysm
This project aims to see if boosting a natural genetic regulator called miR-146a can help slow or prevent growth and rupture of abdominal aortic aneurysms in people with this condition.
-
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Scientists are studying how a molecule called MOF and inflammatory signals affect abdominal aortic aneurysms to find ways to slow or stop their enlargement.
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Endovascular Suturing Device to Improve Endograft Fixation in Abdominal Aortic Aneurysm
A new device aims to better secure endografts during EVAR for abdominal aortic aneurysm to reduce future repairs.
-
Triglyceride-rich lipoproteins and abdominal aortic aneurysm growth
A study exploring how fats in the blood (TRLs) influence the growth of abdominal aortic aneurysms to find non-surgical ways to protect against rupture, especially in people aged 65 and older.
-
Using genetics to uncover how abdominal aortic aneurysms develop
A research team will study how genetic differences influence abdominal aortic aneurysm to help with earlier prevention and better treatment.
-
Phospholipid-based nanotherapies to treat abdominal aortic aneurysm
A new nanoparticle treatment is being developed to slow or stop the growth of abdominal aortic aneurysms in adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.