Investigating a protein that regulates glucose metabolism in the heart during low oxygen conditions
Official title: Arrestin domain-containing protein 4 as a novel regulator of glucose metabolism in the ischemic heart
Funded at City College of New York · NIH-10857225 · Data updated 2026-11-12
This study is looking at how a protein called Arrestin domain-containing protein 4 affects how heart cells use sugar, especially when there's not enough oxygen, to find new ways to help people with heart problems caused by restricted blood flow.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | City College of New York NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $384,650 |
| NIH project number | 5R01HL166620-02 |
| Project ID | NIH-10857225 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with ischemic heart disease or related cardiovascular conditions.
✕Less likely to help
Patients without ischemic heart disease or those with non-cardiovascular metabolic disorders may not benefit from this research.
What this research studies
This research focuses on understanding how a specific protein, Arrestin domain-containing protein 4, influences glucose metabolism in heart cells, especially under conditions where oxygen is limited. The study utilizes advanced techniques, including genetically modified mouse models, to observe how manipulating this protein affects glucose uptake and overall heart function. By exploring the role of this protein, the research aims to uncover new mechanisms that could improve heart health in patients experiencing ischemia, a condition where blood flow is restricted.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance heart function and glucose metabolism in patients with ischemic heart disease.
How similar studies have gone: Previous research has shown promising results in manipulating similar proteins to improve heart function, suggesting that this approach may yield beneficial outcomes.
Where this research is happening
-
City College of New York
New York, United States Active
Researchers
- Principal investigator: Yoshioka, Jun — City College of New York
- Study coordinator: Yoshioka, Jun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.