Investigating a protein that protects brain cells after a stroke
SULT4a1, a novel neuroprotective protein in stroke
This study is looking at a protein called SULT4a1 to see how it helps protect brain cells from damage after a stroke, with the hope of finding new ways to help stroke patients recover better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-10993601 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a protein called SULT4a1 in protecting brain cells from damage caused by stroke. The study aims to identify how SULT4a1 regulates other proteins involved in maintaining cellular health and preventing cell death following a stroke. By exploring the mechanisms of redox balance and mitochondrial function, the research seeks to uncover potential therapeutic targets that could improve recovery outcomes for stroke patients. The approach includes examining the interactions between SULT4a1 and various peroxiredoxins, which are crucial for cellular detoxification processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a stroke and are seeking innovative therapeutic options.
Not a fit: Patients who have not had a stroke or those with conditions unrelated to stroke may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance brain cell survival and recovery after a stroke.
How similar studies have performed: Other research has shown promise in targeting neuroprotective proteins for stroke treatment, indicating that this approach could be beneficial.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Andrabi, Shaida a. — University of Alabama at Birmingham
- Study coordinator: Andrabi, Shaida a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.