Investigating a protein that may help reduce inflammation in a severe intestinal condition in infants.
Inter-alpha Inhibitors in Experimental Necrotizing Enterocolitis
['FUNDING_SBIR_1'] · PROTHERA BIOLOGICS, LLC · NIH-11255387
This study is looking at how a special protein called inter-alpha inhibitor proteins (IAIP) might help reduce inflammation in the intestines of premature babies with a serious condition called necrotizing enterocolitis (NEC), with the hope of finding better treatments to help these little ones recover.
Quick facts
| Phase | ['FUNDING_SBIR_1'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PROTHERA BIOLOGICS, LLC (nih funded) |
| Locations | 1 site (PROVIDENCE, UNITED STATES) |
| Trial ID | NIH-11255387 on ClinicalTrials.gov |
What this research studies
This research focuses on necrotizing enterocolitis (NEC), a serious inflammatory condition affecting the intestines of premature infants. The study aims to explore the role of inter-alpha inhibitor proteins (IAIP) in modulating the inflammatory response associated with NEC. By understanding how IAIP can potentially protect against inflammation and tissue damage, the research seeks to develop new therapeutic strategies to improve outcomes for affected infants. The approach involves analyzing the levels of IAIP in patients and their correlation with disease severity and outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are premature infants who are at risk of developing necrotizing enterocolitis.
Not a fit: Patients who are not premature or do not have necrotizing enterocolitis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce the morbidity and mortality associated with necrotizing enterocolitis in premature infants.
How similar studies have performed: Previous research has shown promising results with similar approaches targeting inflammatory responses in other conditions, suggesting potential for success in this area as well.
Where this research is happening
PROVIDENCE, UNITED STATES
- PROTHERA BIOLOGICS, LLC — PROVIDENCE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIM, YOW-PIN — PROTHERA BIOLOGICS, LLC
- Study coordinator: LIM, YOW-PIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Disease, acute disease/disorder, acute disorder