Investigating a protein that may help improve treatments for pancreatic cancer in African American women.
Official title: Project 2
Funded at Beckman Research Institute/city of Hope · NIH-10933466 · Data updated 2026-11-12
This study is looking at a protein called PIN1 that is linked to pancreatic cancer, and it's trying to create new medicines that could make current treatments work better, especially for African American women who face higher risks from this disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project start | September 22, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $138,776 |
| NIH project number | 5U54CA285116-02 |
| Project ID | NIH-10933466 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are African American women diagnosed with pancreatic cancer.
✕Less likely to help
Patients with pancreatic cancer who do not identify as African American may not receive direct benefits from this research.
What this research studies
This research focuses on a protein called PIN1, which is found in higher levels in pancreatic cancer cells and may contribute to the disease's progression and treatment resistance. The study aims to develop inhibitors for PIN1 that could enhance the effectiveness of existing chemotherapy and immunotherapy treatments. By using advanced techniques like medicinal chemistry and X-ray crystallography, researchers are working to create new drugs that target this protein. The goal is to improve treatment outcomes specifically for African American women who are disproportionately affected by pancreatic cancer.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment options for pancreatic cancer, particularly for African American women.
How similar studies have gone: Other research has shown promise in targeting similar oncogenic pathways, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
-
Beckman Research Institute/city of Hope
Duarte, United States Active
Researchers
- Principal investigator: Raoof, Mustafa — Beckman Research Institute/city of Hope
- Study coordinator: Raoof, Mustafa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.