Investigating a protein network related to Alzheimer's disease
Official title: Functional validation of the SMOC1 matrisomal protein network in Alzheimers disease
Funded at Baylor College of Medicine · NIH-11013864 · Data updated 2026-11-12
This study is looking at certain proteins in the brain to better understand Alzheimer's disease, with the hope that what we learn can help create better treatments for people living with this condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $127,855 |
| NIH project number | 5K01AG080078-03 |
| Project ID | NIH-11013864 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 21 and older who are affected by or at risk for Alzheimer's disease.
✕Less likely to help
Patients with early-stage cognitive impairment not related to Alzheimer's disease may not receive benefit from this research.
What this research studies
This research focuses on understanding the biology of Alzheimer's disease by examining a specific protein network associated with the condition. The approach involves identifying and characterizing key proteins that contribute to the progression of Alzheimer's, using advanced techniques to analyze how these proteins interact and behave under different conditions. The research also aims to discover new therapeutic targets by exploring proteins linked to Alzheimer's triggers across different species. Patients may benefit from the insights gained, which could lead to improved treatments for Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating Alzheimer's disease.
How similar studies have gone: Previous research has shown promise in understanding protein networks in Alzheimer's disease, indicating that this approach could yield valuable insights.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Li-Kroeger, David Edward — Baylor College of Medicine
- Study coordinator: Li-Kroeger, David Edward
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.