Investigating a protein from hepatitis B virus in chronic infections
Official title: A splicing-generated protein of hepatitis B virus in chronic viral infection
Funded at Rhode Island Hospital · NIH-11074981 · Data updated 2026-11-12
This study is looking at a protein made by the hepatitis B virus that might help it stick around in the body, and by understanding how this protein works, we hope to find better ways to manage chronic hepatitis B infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rhode Island Hospital NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project start | July 1, 2024 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $492,000 |
| NIH project number | 1R56AI173101-01A1 |
| Project ID | NIH-11074981 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with chronic hepatitis B infection.
✕Less likely to help
Patients who do not have chronic hepatitis B or those with acute hepatitis may not benefit from this research.
What this research studies
This research focuses on understanding a specific protein generated by the hepatitis B virus (HBV) that may play a role in chronic infections. The study will explore how this protein, known as p43, is produced and its effects on the virus's ability to infect liver cells. By examining the translation and stability of p43, researchers aim to uncover its clinical significance and potential impact on HBV virion secretion and infectivity. This could lead to new insights into managing chronic hepatitis B infections.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for treating chronic hepatitis B infections and reducing the risk of liver cancer.
How similar studies have gone: While the specific approach of studying the p43 protein is novel, similar research on hepatitis B proteins has shown promise in understanding viral behavior and treatment options.
Where this research is happening
-
Rhode Island Hospital
Providence, United States Active
Researchers
- Principal investigator: Tong, Shuping — Rhode Island Hospital
- Study coordinator: Tong, Shuping
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.