Investigating a protein complex that helps prevent allergic asthma
A Cul5 E3 ubiquitin ligase complex that prevents allergic asthma
This study is looking at how a certain protein affects immune cells in people with allergic asthma, hoping to find new ways to reduce inflammation and improve symptoms, using specially modified mice to see what happens when this protein is removed.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10765610 on NIH RePORTER |
What this research studies
This research focuses on understanding how a specific protein complex, known as Cul5 E3 ubiquitin ligase, regulates immune cells involved in allergic asthma. By studying the mechanisms that control the differentiation of T cells, particularly those producing IL-9, the research aims to uncover new pathways that could prevent airway inflammation and remodeling. The approach involves using genetically modified mice to observe the effects of Cul5 deletion on asthma symptoms and immune responses. The findings could lead to novel therapeutic strategies for managing allergic asthma.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with allergic asthma, particularly those experiencing severe symptoms or poor response to existing therapies.
Not a fit: Patients with non-allergic asthma or those whose asthma is not influenced by Th2 or Th9 cell activity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively reduce asthma symptoms and improve the quality of life for patients with allergic asthma.
How similar studies have performed: Previous research has shown promising results in targeting immune pathways for asthma treatment, suggesting that this approach could also be effective.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Oliver, Paula Maria — Children's Hosp of Philadelphia
- Study coordinator: Oliver, Paula Maria
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.