Investigating a protease inhibitor from a specific bacterium for periodontal health
A T.fosythia-derived protease inhibitor in periodontal health and disease
This study is looking at a special protein from a bacteria that might help protect your gums from damage caused by inflammation and bacteria in periodontal disease, with the hope of finding better treatments for people like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Louisville NIH-funded |
| Lab location | 1 site (Louisville, United States) |
| Project ID | NIH-10673635 on NIH RePORTER |
What this research studies
This research focuses on the role of a protease inhibitor derived from the bacterium Tannerella forsythia in managing periodontal disease. It aims to understand how this inhibitor can counteract the harmful effects of proteases released by both bacteria and the immune system during chronic inflammation in the gums. By examining the interactions between this inhibitor and various proteases, the research seeks to develop new therapeutic strategies to protect periodontal tissue from damage. Patients with periodontal disease may benefit from insights gained through this research, potentially leading to improved treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic periodontal disease or those at risk of periodontal tissue damage.
Not a fit: Patients with healthy gums or those without any signs of periodontal disease are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help preserve gum health and prevent tooth loss in patients with periodontal disease.
How similar studies have performed: Previous research has shown promise in using protease inhibitors for managing inflammatory conditions, suggesting that this approach may yield beneficial results.
Where this research is happening
Louisville, United States
- University of Louisville — Louisville, United States (Active)
Researchers
- Principal investigator: Potempa, Jan S — University of Louisville
- Study coordinator: Potempa, Jan S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.