Investigating a potential signaling molecule in a tiny worm
Official title: Exploring the function and shedding of a potential C. elegans Neuregulin
Funded at California State University Northridge · NIH-11056046 · Data updated 2026-11-12
This study is looking at how a special molecule related to EGF helps tiny worms called C. elegans grow and respond to stress, especially how it affects their sleep, which could help us learn more about similar things in people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California State University Northridge NIH-funded |
| Lab location | 1 site (Northridge, United States) |
| Project start | April 15, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $147,500 |
| NIH project number | 5R16NS134541-03 |
| Project ID | NIH-11056046 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in the biological mechanisms of sleep and stress responses, particularly those affected by sleep disorders or related health issues.
✕Less likely to help
Patients who do not have an interest in or are not affected by sleep disorders or cellular stress-related conditions may not receive direct benefits from this research.
What this research studies
This research explores how a specific signaling molecule, related to the Epidermal Growth Factor (EGF), functions in the nematode C. elegans. By studying this model organism, the research aims to understand how EGF signaling affects developmental processes and behaviors, particularly in response to cellular damage. The team will investigate the mechanisms behind a sleep state triggered by stress, which has implications for understanding similar processes in humans. The approach combines genetic and molecular techniques to uncover the role of this signaling pathway.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of sleep regulation and its relationship to cellular stress, potentially leading to new treatments for sleep disorders and related conditions.
How similar studies have gone: Previous research has shown success in using C. elegans to study EGF signaling and its implications for sleep, indicating that this approach is grounded in established scientific methods.
Where this research is happening
-
California State University Northridge
Northridge, United States Active
Researchers
- Principal investigator: Van Buskirk, Cheryl Lynn — California State University Northridge
- Study coordinator: Van Buskirk, Cheryl Lynn
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.