Investigating a peptide that blocks pain signals by targeting specific sodium channels.
Official title: Mechanism of dual Nav1.7 and Nav1.8 block by a NaV inhibitory peptide
Funded at Medical College of Wisconsin · NIH-11074695 · Data updated 2026-11-12
This study is looking at a new substance that could help relieve pain by blocking certain channels in the body that send pain signals, and it's aimed at finding better treatments for people dealing with chronic pain.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | April 15, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $196,250 |
| NIH project number | 5R21NS137014-02 |
| Project ID | NIH-11074695 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic pain conditions that may benefit from targeted pain relief therapies.
✕Less likely to help
Patients who do not experience chronic pain or have conditions unrelated to sodium channel dysfunction may not benefit from this research.
What this research studies
This research focuses on a novel peptide that inhibits two types of sodium channels, NaV1.7 and NaV1.8, which are involved in transmitting pain signals. By understanding how this peptide works, researchers aim to develop a more effective pain relief method that targets multiple pathways rather than just one. The study will explore the mechanisms behind the peptide's action and its potential to reduce the excitability of sensory neurons responsible for pain. If successful, this approach could lead to new analgesic treatments for patients suffering from chronic pain conditions.
Why it matters
Potential benefit: If successful, this research could provide a new, more effective treatment option for patients with chronic pain.
How similar studies have gone: Previous research has shown promise in targeting sodium channels for pain relief, suggesting that this approach could lead to significant advancements in pain management.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Yu, Hongwei — Medical College of Wisconsin
- Study coordinator: Yu, Hongwei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.