Investigating a pathway to improve symptoms of autism spectrum disorder
Official title: Targeting the Pigment Epithelium-Derived Factor (PEDF) Signaling Pathway in Neurodevelopmental Disorders
Funded at Drexel University · NIH-11026376 · Data updated 2026-11-12
This study is looking at how a specific protein called PEDF might help create new treatments for autism that improve a variety of symptoms, not just irritability, by promoting brain growth and connections, using both animal models and human cells to see how it affects social behaviors.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Drexel University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | February 5, 2024 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $158,978 |
| NIH project number | 5R21MH132839-02 |
| Project ID | NIH-11026376 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children and adults diagnosed with autism spectrum disorder.
✕Less likely to help
Patients without a diagnosis of autism spectrum disorder or those with unrelated neurodevelopmental disorders may not benefit from this research.
What this research studies
This research focuses on the role of the Pigment Epithelium-Derived Factor (PEDF) signaling pathway in autism spectrum disorder (ASD). It aims to develop new medications that can address the full range of ASD symptoms, not just irritability, by enhancing neuronal growth and connectivity. The study utilizes animal models and human-derived stem cells to explore how PEDF influences neurite formation and social interaction behaviors. By understanding these mechanisms, the research seeks to identify potential therapeutic targets for improving outcomes in individuals with ASD.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve the quality of life for individuals with autism spectrum disorder.
How similar studies have gone: Previous research has shown promise in targeting similar pathways for neurodevelopmental disorders, indicating potential for success in this approach.
Where this research is happening
-
Drexel University
Philadelphia, United States Active
Researchers
- Principal investigator: Toyo-Oka, Kazuhito — Drexel University
- Study coordinator: Toyo-Oka, Kazuhito
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.