Investigating a pathway that affects Alzheimer's disease progression
Targeting IDOL-ApoE receptor pathway in Alzheimer's disease
This study is looking at how a protein called APOE and its helpers can affect Alzheimer's disease, and it hopes to find ways to help the brain get rid of harmful substances and improve thinking skills, which could lead to new treatments for people with Alzheimer's.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11093417 on NIH RePORTER |
What this research studies
This research focuses on the role of Apolipoprotein E (APOE) and its receptors in Alzheimer's disease (AD). By manipulating the IDOL protein, which regulates these receptors, the study aims to enhance the brain's ability to clear harmful beta-amyloid deposits and improve cognitive function. The approach involves genetic techniques and therapeutic interventions tested in mouse models to understand how these changes can impact AD pathology. Patients may benefit from insights gained that could lead to new treatments targeting these pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults aged 21 and older who are at risk for or diagnosed with Alzheimer's disease.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that slow down or prevent the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in manipulating ApoE receptors to impact Alzheimer's pathology, indicating potential for success in this approach.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Gao, Jie — Ohio State University
- Study coordinator: Gao, Jie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.