Investigating a non-coding RNA's role in the body's internal clock
Functional analysis of a non-coding RNA in the mammalian circadian clock system
This study is looking at how a special type of RNA called Per2AS works with key genes that control our body’s internal clock, which helps us understand how our daily rhythms affect our health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Polytechnic Inst and St Univ NIH-funded |
| Lab location | 1 site (Blacksburg, United States) |
| Project ID | NIH-10488206 on NIH RePORTER |
What this research studies
This research explores how a specific non-coding RNA, known as Per2AS, interacts with core clock genes to regulate the body's circadian rhythms. By analyzing the rhythmic expression of this RNA and its relationship with the Period2 gene, the study aims to uncover its functional role in maintaining the body's internal clock. The approach involves detailed molecular analyses and experiments to understand how these interactions affect cellular behavior and overall physiology. Patients may benefit from insights gained about circadian rhythms and their impact on health.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals experiencing sleep disorders or other health issues linked to circadian rhythm disruptions.
Not a fit: Patients who do not have any circadian rhythm-related health issues may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing conditions related to circadian rhythm disruptions, such as sleep disorders and metabolic diseases.
How similar studies have performed: While the role of non-coding RNAs in biological processes is an emerging field, similar studies have shown promising results in understanding their functions, suggesting potential for success in this area.
Where this research is happening
Blacksburg, United States
- Virginia Polytechnic Inst and St Univ — Blacksburg, United States (Active)
Researchers
- Principal investigator: Kojima, Shihoko — Virginia Polytechnic Inst and St Univ
- Study coordinator: Kojima, Shihoko
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.