Investigating a new way to treat nausea and vomiting
Targeting the GDF15-GFRAL system to treat nausea and emesis
This study is looking at how a protein called GDF15 affects feelings of nausea and vomiting, especially for people going through chemotherapy, with the hope of finding new ways to help ease these uncomfortable symptoms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10849924 on NIH RePORTER |
What this research studies
This research focuses on the role of a protein called GDF15 and its interaction with a receptor known as GFRAL in the brain, which may influence feelings of nausea and vomiting. By understanding how GDF15 affects these sensations, especially in patients undergoing chemotherapy, the researchers aim to develop new treatments that can alleviate these distressing symptoms. The study will involve analyzing how GDF15 signaling impacts appetite and nausea, particularly in conditions like cancer and obesity. Patients may be monitored for changes in their symptoms and responses to potential new therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients experiencing nausea and vomiting due to chemotherapy or other related conditions.
Not a fit: Patients who do not experience nausea or vomiting, or those not undergoing chemotherapy, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for nausea and vomiting, particularly for patients undergoing chemotherapy.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways for nausea and vomiting, suggesting potential for success in this approach.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: De Jonghe, Bart C — University of Pennsylvania
- Study coordinator: De Jonghe, Bart C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.