Investigating a new way to target lung cancer growth and spread
CARM1-mediated regulation of YAP1 as a therapeutic target in lung cancer
This study is looking at how two proteins, CARM1 and YAP1, affect the growth of non-small cell lung cancer, with the hope of finding new ways to treat the disease and help patients live better lives.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | H. Lee Moffitt Cancer Ctr & Res Inst NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-10832590 on NIH RePORTER |
What this research studies
This research focuses on understanding how certain proteins, specifically CARM1 and YAP1, influence the growth and spread of non-small cell lung cancer (NSCLC). By examining the interactions between these proteins and their regulation, the study aims to uncover new therapeutic targets that could inhibit cancer progression. The researchers will use various laboratory techniques, including cell cultures and animal models, to explore these mechanisms in detail. Patients may benefit from potential new treatments that arise from this research, which could improve outcomes for those with NSCLC.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with non-small cell lung cancer, particularly those with K-Ras mutations.
Not a fit: Patients with other types of lung cancer or those without the specific genetic mutations being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that specifically target the mechanisms driving lung cancer growth and metastasis.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in cancer treatment, indicating potential for success in this approach.
Where this research is happening
Tampa, United States
- H. Lee Moffitt Cancer Ctr & Res Inst — Tampa, United States (Active)
Researchers
- Principal investigator: Kissil, Joseph — H. Lee Moffitt Cancer Ctr & Res Inst
- Study coordinator: Kissil, Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.