Investigating a new vaccine for bacterial diarrhea caused by E. coli.
Evaluation of Memory Responses and Biomarkers from a Phase IEnterotoxigenic Escherichia coli (ETEC) Intramuscular SubunitVaccine with dmLT Adjuvant
This study is testing a new vaccine to help protect kids and military personnel from a common cause of diarrhea called E. coli, and it looks at how different doses of the vaccine can boost the body's immune response.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project ID | NIH-10897984 on NIH RePORTER |
What this research studies
This research focuses on developing a vaccine to protect against Enterotoxigenic E. coli (ETEC), a leading cause of bacterial diarrhea, particularly in children and military personnel. The study builds on a previous Phase 1 trial that tested a vaccine using specific components of the bacteria combined with an adjuvant to enhance immune response. Researchers will analyze blood samples from trial participants to identify key biomarkers and understand how different vaccine doses affect immune memory and response. This work aims to improve vaccine effectiveness and longevity of protection against ETEC.
Who could benefit from this research
Good fit: Ideal candidates for this research include children, travelers, and military personnel who are at risk of ETEC infections.
Not a fit: Patients who are not at risk for ETEC infections or those who have already been vaccinated against it may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a safe and effective vaccine that significantly reduces the incidence of bacterial diarrhea caused by ETEC.
How similar studies have performed: Previous vaccine trials targeting ETEC have shown promising results, indicating that this approach has potential for success.
Where this research is happening
New Orleans, United States
- Tulane University of Louisiana — New Orleans, United States (Active)
Researchers
- Principal investigator: Norton, Elizabeth B — Tulane University of Louisiana
- Study coordinator: Norton, Elizabeth B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.