Investigating a new treatment target for obesity
Validation of ALDH1A1 as a target for the treatment of obesity: effects of ALDH1A1 inhibition on energy metabolism
['FUNDING_R01'] · UNIVERSITY OF WASHINGTON · NIH-10875557
This study is looking at a new way to help people with obesity by testing a special compound called N42 that targets a specific enzyme, hoping it can boost energy use and support weight loss.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10875557 on ClinicalTrials.gov |
What this research studies
This research focuses on validating ALDH1A1 as a target for obesity treatment by testing a novel inhibitor called N42. The study aims to understand how inhibiting this enzyme can affect energy metabolism and potentially lead to weight loss. By examining the effects of this inhibitor in animal models, researchers hope to develop safe and effective drugs that can help manage obesity in humans. The approach involves detailed analysis of metabolic processes in key tissues like the liver and adipose tissue.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are struggling with obesity.
Not a fit: Patients who are not overweight or obese may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, effective treatments for obesity that minimize side effects.
How similar studies have performed: Previous research has shown promise in targeting similar metabolic pathways for obesity treatment, indicating potential for success with this approach.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PAIK, JISUN — UNIVERSITY OF WASHINGTON
- Study coordinator: PAIK, JISUN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.