Investigating a new treatment target for non-small cell lung cancer
Evaluation of PARP7 dependency as a novel therapeutic target for non-small cell lung cancer
This study is looking at a protein called PARP7 to see if targeting it can help boost the immune system's fight against non-small cell lung cancer, with the goal of finding better treatments for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Greater Los Angeles Healthcare System NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10695528 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of PARP7, a specific protein, in non-small cell lung cancer (NSCLC), which is a common type of lung cancer. The study aims to evaluate how targeting PARP7 can enhance the body's immune response against tumors and improve treatment outcomes. By analyzing the dependency of NSCLC tumors on PARP7, researchers hope to develop a diagnostic platform and therapeutic strategies that could lead to more effective treatments for patients. The approach combines bioinformatics and clinical assessments to identify patients who may benefit from this targeted therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with non-small cell lung cancer, particularly those who may not have responded well to existing therapies.
Not a fit: Patients with other types of lung cancer or those whose tumors do not exhibit PARP7 dependency may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment options for patients with non-small cell lung cancer.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in cancer treatment, indicating potential for success in this novel approach.
Where this research is happening
Los Angeles, United States
- VA Greater Los Angeles Healthcare System — Los Angeles, United States (Active)
Researchers
- Principal investigator: Dubinett, Steven M. — VA Greater Los Angeles Healthcare System
- Study coordinator: Dubinett, Steven M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.