Investigating a new treatment target for dry eye disease
Roles of CaSR in ocular surface health and disease
This study is looking at a new way to help people with dry eye disease by testing a special treatment that could improve eye moisture and reduce discomfort.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11079447 on NIH RePORTER |
What this research studies
This research focuses on dry eye disease (DED), a condition characterized by reduced hydration of the ocular surface, leading to inflammation and damage. The study aims to explore the role of the calcium-sensing receptor (CaSR) in the eye, which has been found to influence ion transport and tear fluid production. By testing CaSR inhibitors in animal and human cell models, the research seeks to develop a novel treatment that could improve hydration and reduce symptoms of DED. The approach includes both laboratory studies and potential clinical applications.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who experience symptoms of dry eye disease.
Not a fit: Patients with dry eye disease who do not respond to treatments targeting the calcium-sensing receptor may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a new treatment option for patients suffering from dry eye disease, improving their quality of life.
How similar studies have performed: Previous research has shown promise in targeting similar pathways for treating ocular conditions, suggesting potential for success in this novel approach.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Cil, Onur — University of California, San Francisco
- Study coordinator: Cil, Onur
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.