Investigating a new treatment target for advanced prostate cancer
A novel targetable mechanism for castration-resistant prostate cancer
This study is looking at why some prostate cancers stop responding to hormone treatments, and it's trying to find new ways to help patients by exploring how certain signals in the cancer cells work together.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Long Beach, United States) |
| Project ID | NIH-10881633 on NIH RePORTER |
What this research studies
This research focuses on understanding the mechanisms behind castration-resistant prostate cancer (CRPC), a severe form of prostate cancer that does not respond to standard hormone therapies. The team aims to identify new therapeutic targets by studying the role of specific signaling pathways, particularly the Wnt/β-catenin signaling and its interaction with androgen receptor signaling. By analyzing the genetic and molecular changes in CRPC, the researchers hope to develop innovative treatment strategies that could improve outcomes for patients. This work involves laboratory experiments and analysis of cancer cell behavior to uncover potential new treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are veterans diagnosed with castration-resistant prostate cancer who have not responded to standard anti-androgen therapies.
Not a fit: Patients with early-stage prostate cancer or those who have not yet undergone hormone therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment options for patients with castration-resistant prostate cancer.
How similar studies have performed: Previous research has shown promise in targeting similar pathways in cancer treatment, indicating potential for success in this novel approach.
Where this research is happening
Long Beach, United States
- Veterans Health Administration — Long Beach, United States (Active)
Researchers
- Principal investigator: Zi, Xiaolin — Veterans Health Administration
- Study coordinator: Zi, Xiaolin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.