Investigating a new treatment pathway for bladder issues in aging men
Official title: Nitric Oxide-Soluble Guanylate Cyclase Pathway as a Target for Male Bladder Outlet Obstruction and Lower Urinary Tract Symptoms in Aging
Funded at University of Pittsburgh at Pittsburgh · NIH-10910129 · Data updated 2026-11-12
This study is looking at how a specific pathway in the body can help improve treatment for men dealing with bladder issues caused by an enlarged prostate, especially as they get older, and aims to find new options that work better and have fewer side effects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | August 19, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $671,019 |
| NIH project number | 5R01DK134386-02 |
| Project ID | NIH-10910129 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are aging men experiencing bladder outlet obstruction or lower urinary tract symptoms related to benign prostatic hyperplasia.
✕Less likely to help
Patients who are not experiencing bladder outlet obstruction or lower urinary tract symptoms, or those who are not male, may not benefit from this research.
What this research studies
This research focuses on understanding how the nitric oxide-soluble guanylate cyclase pathway can be targeted to improve treatment for men suffering from bladder outlet obstruction and lower urinary tract symptoms due to benign prostatic hyperplasia. The study aims to explore the underlying mechanisms of these conditions, particularly in aging populations, and evaluate new therapeutic options that may be more effective and have fewer side effects than current treatments. By examining the role of nitric oxide in bladder function, the research seeks to identify innovative strategies to alleviate symptoms and improve quality of life for affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for bladder outlet obstruction and urinary symptoms, enhancing the quality of life for many aging men.
How similar studies have gone: Previous research has shown promise in targeting similar pathways for treating urinary symptoms, indicating potential for success in this novel approach.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Kanai, Anthony John — University of Pittsburgh at Pittsburgh
- Study coordinator: Kanai, Anthony John
Related research
Other NIH-funded projects on the same topics.
-
Nitric Oxide Pathway as a Target for Male BPH and LUTS in Aging
A patient-facing program exploring how a nitric oxide pathway might help men with aging-related urinary symptoms from enlarged prostate.
-
Understanding a key pathway for bladder issues in aging men
This research explores a specific body pathway to find new ways to help aging men with common bladder problems like frequent urination and difficulty emptying their bladder.
-
Aging Well with HIV: Alcohol, Risk Reduction, and Education Center (AWAR3E)
A center at Yale is exploring how aging with HIV interacts with alcohol use to create inflammation and frailty, with the goal of finding biomarkers and potential treatments.
-
Cognitive SuperAging: Exploring why some octogenarians stay sharp in memory
This NIH grant studies why a small group of people aged 80+ keep memory skills as good as much younger people, hoping to understand how to protect memory as we age.
-
Biological aging across the lifespan through a national high school-to-adult study
This grant uses a long-running national study of students and adults to collect saliva biomarkers of aging, alongside surveys, to understand how aging markers relate to health and life experiences.
-
Understanding how aging and Alzheimer’s affect how people make tough choices
This NIH grant studies how aging and Alzheimer’s risk change how people decide between immediate and delayed rewards and risky options, with the goal of helping older adults stay financially and healthwise safer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.