Investigating a new treatment for seizures using a specific inhibitor in mice
Official title: Testing the effects of a selective calpain-2 inhibitor on spontaneous recurrent seizures in mouse models of epilepsy
Funded at Neuraegis, INC. · NIH-11075014 · Data updated 2026-11-12
This study is looking at how a special treatment might help reduce seizures in mice with epilepsy, especially when the condition starts after injuries like strokes or head trauma, and it uses a method that could be easier and safer than current treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Neuraegis, INC. NIH-funded |
| Lab location | 1 site (Irvine, UNITED STATES) |
| Project start | September 1, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $19,487 |
| NIH project number | 3R41NS130825-02S1 |
| Project ID | NIH-11075014 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with epilepsy, particularly those who have experienced seizures following an initial brain injury.
✕Less likely to help
Patients with epilepsy that is not linked to initial brain injuries or those who do not respond to calpain-2 inhibition may not benefit from this research.
What this research studies
This research explores the effects of a selective calpain-2 inhibitor on spontaneous recurrent seizures in mouse models of epilepsy. The study aims to understand how this inhibitor can potentially prevent the progression of epilepsy, particularly in cases triggered by initial injuries like strokes or traumatic brain injuries. By using intranasal delivery for the treatment, the research seeks to enhance efficacy and reduce side effects compared to traditional methods. The findings could lead to new therapeutic strategies for managing epilepsy more effectively.
Why it matters
Potential benefit: If successful, this research could lead to a novel treatment that reduces seizure frequency and severity in patients with epilepsy.
How similar studies have gone: While the approach of using calpain inhibitors is promising, it is relatively novel and has not been extensively tested in human subjects for epilepsy treatment.
Where this research is happening
-
Neuraegis, INC.
Irvine, United States Active
Researchers
- Principal investigator: Baudry, Michel — Neuraegis, INC.
- Study coordinator: Baudry, Michel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.