Investigating a new treatment for liver disease caused by alcohol
Role of Soluble Epoxide Hydrolase in Alcohol-Associated Liver Disease
This study is looking at how a specific enzyme might help improve liver health for people dealing with alcohol-related liver problems, and it aims to find out if blocking this enzyme can reduce liver damage at different stages of the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Louisville NIH-funded |
| Lab location | 1 site (Louisville, United States) |
| Project ID | NIH-11052556 on NIH RePORTER |
What this research studies
This research focuses on alcohol-associated liver disease (ALD), which includes various liver disorders resulting from alcohol consumption. The study aims to explore the role of soluble epoxide hydrolase (s-EH), an enzyme that may be a key target for new therapies. Researchers will test the effectiveness of inhibiting s-EH to see if it can reduce liver injury at different stages of ALD. By understanding how s-EH affects liver health, the research hopes to provide a foundation for developing new treatments for patients suffering from alcohol-related liver issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with alcohol-associated liver disease, including those at various stages of the condition.
Not a fit: Patients who do not have alcohol-associated liver disease or those with liver conditions unrelated to alcohol may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for patients with alcohol-associated liver disease, potentially improving their health outcomes.
How similar studies have performed: While the role of s-EH in liver disease is a relatively new area of investigation, preliminary studies suggest that targeting this enzyme may offer promising therapeutic avenues.
Where this research is happening
Louisville, United States
- University of Louisville — Louisville, United States (Active)
Researchers
- Principal investigator: Kirpich, Irina a. — University of Louisville
- Study coordinator: Kirpich, Irina a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.