Investigating a new treatment for functional dyspepsia
Official title: Pharmacodynamics, Pharmacogenetics, Clinical Efficacy and Safety of Tradipitant for Functional Dyspepsia
Funded at Mayo Clinic Rochester · NIH-10798325 · Data updated 2026-11-12
This study is looking at how a new medication called tradipitant can help people with functional dyspepsia, which causes ongoing stomach pain and discomfort, by checking how well it works and how safe it is compared to other treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | April 20, 2022 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $304,468 |
| NIH project number | 5R01DK131946-03 |
| Project ID | NIH-10798325 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing chronic abdominal pain and discomfort associated with eating, specifically those diagnosed with functional dyspepsia.
✕Less likely to help
Patients who do not have functional dyspepsia or those whose symptoms are caused by other gastrointestinal disorders may not benefit from this research.
What this research studies
This research focuses on understanding how a new medication, tradipitant, can help patients suffering from functional dyspepsia, a condition characterized by persistent abdominal pain and discomfort. The study will explore the medication's effects on gastric function and its safety and efficacy in alleviating symptoms. Patients will undergo noninvasive imaging to assess their gastric accommodation and emptying, which are often disrupted in those with this condition. By comparing tradipitant to existing treatments, the research aims to identify a more effective solution for managing functional dyspepsia.
Why it matters
Potential benefit: If successful, this research could provide a new, effective treatment option for patients suffering from functional dyspepsia.
How similar studies have gone: Previous research has shown promise with similar approaches using NK1 receptor antagonists, indicating potential for success in this area.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Wang, Xiao Jing — Mayo Clinic Rochester
- Study coordinator: Wang, Xiao Jing
Related research
Other NIH-funded projects on the same topics.
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Vagus nerve stimulation plus cognitive behavioral therapy to ease functional dyspepsia symptoms
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Exploring the effects of vagal stimulation and therapy on gut-brain interactions in functional dyspepsia
This study is looking at whether using a device that stimulates the vagus nerve along with talking therapy can help people with functional dyspepsia feel better and improve their quality of life.
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Understanding eating problems in adults with functional dyspepsia
This study is looking at the eating challenges faced by adults with functional dyspepsia to understand what makes it hard for them to eat and to test a new program that could help them enjoy a wider variety of foods again.
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Investigating how different acupuncture points affect the gut-brain connection in functional dyspepsia.
This study is looking at how acupuncture might help people with functional dyspepsia by seeing how it affects the brain and stomach, using special imaging techniques to track any changes during treatment.
-
Evaluating the effectiveness of Danning Tablets for digestive symptoms
This study is testing if Danning Tablets can help people aged 18 to 75 feel better from digestive issues like indigestion and bloating while they are already using the medication.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.