Investigating a new treatment for functional dyspepsia
Pharmacodynamics, Pharmacogenetics, Clinical Efficacy and Safety of Tradipitant for Functional Dyspepsia
This study is looking at how a new medication called tradipitant can help people with functional dyspepsia, which causes ongoing stomach pain and discomfort, by checking how well it works and how safe it is compared to other treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10798325 on NIH RePORTER |
What this research studies
This research focuses on understanding how a new medication, tradipitant, can help patients suffering from functional dyspepsia, a condition characterized by persistent abdominal pain and discomfort. The study will explore the medication's effects on gastric function and its safety and efficacy in alleviating symptoms. Patients will undergo noninvasive imaging to assess their gastric accommodation and emptying, which are often disrupted in those with this condition. By comparing tradipitant to existing treatments, the research aims to identify a more effective solution for managing functional dyspepsia.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing chronic abdominal pain and discomfort associated with eating, specifically those diagnosed with functional dyspepsia.
Not a fit: Patients who do not have functional dyspepsia or those whose symptoms are caused by other gastrointestinal disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new, effective treatment option for patients suffering from functional dyspepsia.
How similar studies have performed: Previous research has shown promise with similar approaches using NK1 receptor antagonists, indicating potential for success in this area.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Wang, Xiao Jing — Mayo Clinic Rochester
- Study coordinator: Wang, Xiao Jing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.